… study is the first report of long-term administration of a T-type calcium channel blocker in
hyperinsulinemic, insulin-resistant and hypertensive rats. Chronic mibefradil treatment of FH rats …

… the relatively selective Ttype calcium antagonist mibefradil (10 p#… with severe and malignant
arterial hypertension were … points during a hyperinsulinemic isoglycemic glucose clamp and …

… and reducing hyperinsulinemia (116). It has been demonstrated that … Chronic T-type Ca2+
channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats…

… nM, mibefradil exhibited no long-term effect on the T-type Ca … whether mibefradil or dm-mibefradil
inhibits L- or T-type Ca 2… hyperinsulinemia (Verma et al., 1997). Our results show that …

… Table 2 General characteristics of rats in the 4 experimental groups in the reversal study …
Fructose hypertensive rats (8 weeks fructose-fed) and their age and weight matched control …

… rats, we studied the effects of mibefradil (a calcium channel … examined the chronic effects of
a calcium antagonist (mibefradil) … blocks the T-type calcium channels. Although the available …

… to mibefradil but more selective for T-type Ca 2+ channels, but … may play a role in the
pathogenesis of hyperinsulinemia in … The hallmark of diabetes mellitus is chronically high fasting …

… Long-term treatment with the T-type Ca 2+ channel blocker, mibefradil, both prevented and
reversed the development of hyperinsulinemia in an insulin-resistant and hypertensive rat …

… In this study we compared the long-term effects of mibefradil with those of cilazapril, an ACE
… the T-type calcium channel blocker mibefradil prevents the development of hypertension, …

… Mibefradil, which acts as a T-type calcium channel blocker, … the effects and mechanism
of mibefradil on high-glucose–… rate, reduces hyperglycemia and hyperinsulinemia, and has …